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| FSL construct ： ウィキペディア英語版 |
Function-spacer-lipid construct
Function-spacer-lipid constructs (FSL constructs) are amphiphatic, water dispersible biosurface engineering constructs that can be used to engineer the surface of cells, viruses and organisms, or to modify solutions and non-biological surfaces with bioactives.〔〔 FSL constructs spontaneously and stably incorporate into cell membranes. FSL constructs with all these aforementioned features are also known as Kode™ Constructs.〔 The process of modifying surfaces with FSL constructs is known as "koding" and the resultant "koded" cells,〔 viruses and liposomes are respectively known as kodecytes,〔〔 kodevirions〔〔 and kodesomes.
==Technology description==
All living surfaces are decorated with a diverse range of complex molecules, which are key modulators of chemical communications and other functions such as protection, adhesion, infectivity, apoptosis, etc. Functional-Spacer-Lipid (FSL) constructs can be synthesized to mimic the bioactive components present on biological surfaces, and then re-present them in novel ways.〔〔
The architecture of an FSL construct, as implicit in the name, consists of three components - a functional head group, a spacer, and a lipid tail.〔 This structure is analogous to a flowering plant in that they have three structural components, with each component having a separate purpose.〔〔 In the examples shown in all the figures a sunflower has been used for the analogy. However, it should be appreciated that this is merely a representation and the true structural similarity is significantly varied between flowers and FSL constructs ''(fig 2)''. The functional group of an FSL is equivalent to a flower head, with both being at the extremity and carrying the functional components. The spacer of the FSL is equivalent to the stalk of the flower and the leaves on the stalk are representative of substitutions which may be engineered into the chemical makeup of the spacer. The lipid of the FSL anchors it to lipid membranes and gives the FSL construct its amphiphatic nature which can cause it to self-assemble. Because the lipid tail can act directly as an anchor it is analogous to the root system of a plant.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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